Kirkman® offers Trimethylglycine (TMG) in 175 mg capsules with folic acid and vitamin B-12.  This hypoallergenic formulation was especially designed for individuals with special requirements and sensitivities.

Kirkman’s TMG is derived from beets, which is the commercially available source.  TMG is dimethylglycine (DMG) with one more methyl group.  The chemical structure of TMG is a glycine molecule holding onto three methyl groups.  Like DMG, TMG is considered a "methyl donor" or “methyl bank."  The additional methyl group makes TMG a more active methyl donor than DMG, which provides a benefit to some individuals.  TMG can support the formation of methionine by methylating homocysteine.  Some of this methionine eventually is converted into SAMe (S-adenosylmethionine), which can help maintain healthy serotonin levels in the body, thus supporting mood and a feeling of well-being.  As with DMG, TMG plus a coenzyme of riboflavin supplies methyl groups that attach to folic acid to form methylenetetrahydrofolate, an important component of many biochemical processes in the body including cellular perception and response.

This Kirkman® formulation also includes folic acid and vitamin B-12. Folic acid intake and levels in the body must be adequate for TMG to work biochemically.  For this reason, some physicians recommend a TMG supplement containing folic acid.  Because folic acid can sometimes mask a vitamin B-12 deficiency, vitamin B-12 has also been included in this formulation.  Furthermore, it is known that vitamin B-12 works synergistically with folic acid. The most active form of vitamin B-12 in folate chemistry is methylcobalamin, and Kirkman® utilizes this form of vitamin B-12 in this product, which may assist methionine metabolism, methylation, and folate chemistry.